International Conference Large Scale Scientific Computations (LSSC'21)
7-11 June 2021, Sozopol, Bulgaria & online

Computational Study of IL-6 Inhibition by Low-Molecular-Weight Heparin

International Conference BIOMATH 2021
20-25 June 2021, Pretoria, South Africa & online

Molecular mechanism of the anti-inflammatory action of heparin: a computational perspective of the COVID-19 case

AMiTaNS'2021, June 24-29, 2021, Albena, Bulgaria & online

LMWH as a prospective IL-6 blocker: a computational study

International Workshop "Mathematics of Life (MoL2021)"
13-16 September 2021, Hisarya, Bulgaria & online

In silico study of the molecular mechanism of LMWH antiinflammatory action within the Covid-19 context

Workshop on Numerical and Symbolic Scientific Computing
20-23 September 2021, Sofia, Bulgaria & online

Cytokines activity impairment through heparin - molecular mechanism and therapeutic potential

PRACE Autumn School: Fundamentals of Biomolecular Simulations and Virtual Drug Development
20-24 September 2021, online

In silico study of the antiinflammatory action of heparin within the Covid-19 context

Numerical Solution of Fractional Differential Equations and Applications (NSFDE&A'22)
June 5 - 10, 2022, Sozopol, Bulgaria

Computational modeling of the replicase-transcriptase complex of SARS-CoV-2

14th Conference of the Euro-American Consortium for Promoting the Application of Mathematics in Technical and Natural Sciences, (AMiTaNS'22)
Albena, Bulgaria, June 22-27, 2022 & online

Computational approach to the inhibition of SARS-CoV-2 ORF6

10th International Conference on Numerical Methods and Applications (NM&A'22)
August 22 - 26, 2022, Borovets, Bulgaria & online

Blocking the immunosuppressing action of the ORF6 protein of the SARS-CoV-2 virus: computational assays

4th International Symposium on Frontiers in Molecular Science: Biochemistry, Molecular Biology and Druggability of Proteins - ISFMS'2022
06-09 September 2022, Florence, Italy

Human interferon gamma is a potential inhibitor of SARS-Cov-2 ORF6 activity

The 100 anniversary of the birth of Acad. Roumen Tsanev conference
5-7 October 2022, Sofia, Bulgaria

Biomolecule Studies: A Computational Perspective

The 100 anniversary of the birth of Acad. Roumen Tsanev conference
5-7 October 2022, Sofia, Bulgaria

Study on the toxic effect of SARS-CoV-2 ORF6 protein

[1] Ca2+ -dependent mechanism of membrane insertion
and destabilization by the SARS-CoV-2 fusion peptide

George Khelashvili, Ambrose Plante, Milka Doktorova, and Harel Weinstein

Biophysical Journal 120 (2021) 1105-1119; link

[1] In silico structure modelling of SARS-CoV-2 Nsp13 helicase and Nsp14 and repurposing of FDA approved antiviral drugs as dual inhibitors

Arun Bahadur Gurung

Gene Reports Volume 21 (2020) 100860; link

[2] SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists

Chun-Kit Yuen et al.

Emerging Microbes & Infections Vol. 9 (2020); link

[3] Force-dependent stimulation of RNA unwinding by SARS-CoV-2 nsp13 helicase

Keith J. Mickolajczyk et al.

Biophysical Journal 120 (2021) 1020-1030; link

[4] SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms

Christine Vazquez et al.

PLoS ONE (2021) 16(6): e0253089; link

[1] SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

Lisa Miorin et al.

PNAS vol. 117, no. 45 (2020) 28344-28354; link

[2] Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor

Jin Gu Lee et al.

Cell Biosci (2021) 11:58; link

[3] Molecular Mechanism of SARS-CoVs Orf6 Targeting the Rae1-Nup98 Complex to Compete With mRNA Nuclear Export

Tinghan Li, Yibo Wen, Hangtian Guo, Tingting Yang, Haitao Yang, and Xiaoyun Ji1

Front. Mol. Biosci.(2022); link

Perspective on computational simulations of glycosaminoglycans

Balaji Nagarajan, Nehru Viji Sankaranarayanan, and Umesh R. Desai

Wiley Interdiscip Rev Comput Mol Sci. 9(2)(2019):e1388; link