Scope & Objectives


Human interferon-gamma (hIFNγ) is a crucial immunomodulating pleotropic cytokine, its biological effects ranging from proliferation to apoptosis. It can increase both the innate and adaptive immune response against pathogens and tumours while maintaining immune homeostasis. However, when overexpressed, hIFNγ can lead to autoimmune pathology (including multiple sclerosis, myasthenia gravis, systemic lupus erythematous, rheumatoid arthritis and even the atherosclerosis and the post transplant atherosclerosis), inflammation, neurodegenerative diseases, and cancer. Also in the acute phase of COVID-19, the disease caused by the novel corona virus SARS-CoV-2, the overproduction of proinflammatory cytokines, particularly IL-6 and IFNγ, Hall_Hisar triggers a state of overreaction, the so-called cytokine storm, which seems to be the main contributor towards a fatal outcome of the illness. The treatment of such states may benefit from the inhibition of hIFNγ receptor, signal transduction or hIFNγ molecule.

The Workshop will focus on new approaches for fine regulation of the activity of endogenous hIFNγ. It will take place in HISAR Hall at Hotel Augusta, Hisarya.

Three types of talks are planned: 45, 35 and 30 minutes respectively, including time for discussions. No poster session is foreseen. The morning sessions on 19th and 20th May will be focused on topics within the scope of the EUropean TOPology Interdisciplinary Action (COST Action CA17139, EUTOPIA).

Programme Scheme

Time 10 May 11 May 12 May 13 May
9:30 - 10:15 Genoveva Nacheva Leandar Litov Nevena Ilieva
10:15 - 10:45 Elena Krachmarova Peicho Petkov Summary & Outlook
10:45 - 11:15 Coffee break Coffee break
11:15 - 12:00 Anastas Gospodinov Student Session
12:00 - 14:00 Lunch break Lunch break Lunch break
14:00 - 14:30 Anastas Pashov
(p II)
Miroslav Rangelov Departure
14:30 - 15:00 Elena Lilkova
15:00 - 15:30 Registration Kristina Malinova Nadezhda Todorova
15:30 - 16:00 Coffee break Coffee break
16:00 - 16:30 Opening Working groups Working groups
16:30 - 17:00 Anastas
Pashov (p I)
Working groups Working groups
17:00 - 18:00 Discussion Discussion Discussion


Lorem ipsum bla bla bl .


Financial & IT Support

• Bulgarian National Science Fund: Project "A complex approach to engineering of novel immunomodulating biologicals" (DN-11/20/2017)

• Bulgarian National Science Fund: Project "Search for ligands unblocking the innate immune response in cells infected with SARS-CoV-2 virus" (KP-06-DK1/5/2021)

• Centre for Advanced Computing and Data Processing, financed under the Science and Education for Smart Growth Operational Program (2014-2020), Grant No BG05M2OP001-1.001-0003