Therapeutic potential of human interferon gamma
and its mutant derivatives
(THERINF-G)
May 10-13, 2022, Hisarya, Bulgaria
Scope & Objectives
Human interferon-gamma (hIFNγ) is a crucial immunomodulating pleotropic cytokine, its biological effects ranging from
proliferation to apoptosis. It can increase both the innate and adaptive immune response against pathogens and tumours while
maintaining immune homeostasis. However, when overexpressed, hIFNγ can lead to autoimmune pathology (including multiple sclerosis,
myasthenia gravis, systemic lupus erythematous, rheumatoid arthritis and even the
atherosclerosis and the post transplant atherosclerosis), inflammation, neurodegenerative diseases, and cancer.
Also in the acute phase of COVID-19, the disease caused by the novel corona virus
SARS-CoV-2, the overproduction of proinflammatory cytokines, particularly IL-6 and IFNγ,
triggers a state of overreaction,
the so-called cytokine storm, which seems to be the main contributor towards a fatal outcome of the illness.
The treatment of such states may benefit from the inhibition of hIFNγ receptor, signal transduction or hIFNγ
molecule.
The Workshop will focus on new approaches for fine regulation of the activity of endogenous hIFNγ. It will take place in HISAR Hall at Hotel Augusta, Hisarya.
Three types of talks are planned: 45, 35 and 30 minutes respectively, including time for discussions. No poster session is foreseen.
The morning sessions on 19th
and 20th May will be focused on topics within the scope of the EUropean TOPology Interdisciplinary Action (COST Action CA17139, EUTOPIA).
Programme Scheme
| Time | 10 May | 11 May | 12 May | 13 May |
|---|---|---|---|---|
| 9:30 - 10:15 | Genoveva Nacheva | Leandar Litov | Nevena Ilieva | |
| 10:15 - 10:45 | Elena Krachmarova | Peicho Petkov | Summary & Outlook | |
| 10:45 - 11:15 | Coffee break | Coffee break | ||
| 11:15 - 12:00 | Anastas Gospodinov | Student Session | ||
| 12:00 - 14:00 | Lunch break | Lunch break | Lunch break | |
| 14:00 - 14:30 | Anastas Pashov (p II) |
Miroslav Rangelov | Departure | |
| 14:30 - 15:00 | Elena Lilkova | |||
| 15:00 - 15:30 | Registration | Kristina Malinova | Nadezhda Todorova | |
| 15:30 - 16:00 | Coffee break | Coffee break | ||
| 16:00 - 16:30 | Opening | Working groups | Working groups | |
| 16:30 - 17:00 | Anastas Pashov (p I) |
Working groups | Working groups | |
| 17:00 - 18:00 | Discussion | Discussion | Discussion |
Participants
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Gallery
Financial & IT Support
• Bulgarian National Science Fund: Project "A complex approach to engineering of novel immunomodulating biologicals" (DN-11/20/2017)
• Bulgarian National Science Fund: Project "Search for ligands unblocking the innate immune response in cells infected with SARS-CoV-2 virus" (KP-06-DK1/5/2021)
• Centre for Advanced Computing and Data Processing, financed under the Science and Education for Smart Growth Operational Program (2014-2020), Grant No BG05M2OP001-1.001-0003
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